Reacción #604982

Ecuación de reacción

sodium borohydride

3-chloro-6-(morpholin-4-yl)[1,2,4]triazolo[4,3-b]pyridazine

1,1-dimethylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate

→

1,1-dimethylethyl (6-{[6-(morpholin-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate

Rendimiento 42.5%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction is refluxed for 23 h
2. 2
   Concentraciónis then concentrated to dryness under vacuum
3. 3
   OtroThe product is chromatographed by solid deposit on a Merck cartridge of 70 g of silica 15-40 μm, elution

Procedimiento

68 mg of sodium borohydride are added to a mixture of 430 mg of 3-chloro-6-(morpholin-4-yl)[1,2,4]triazolo[4,3-b]pyridazine and 510 mg of 1,1-dimethylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate in 9 cm3 of degassed ethanol and then the reaction is refluxed for 23 h. The suspension is left at 20° C. overnight and is then concentrated to dryness under vacuum. The product is chromatographed by solid deposit on a Merck cartridge of 70 g of silica 15-40 μm, elution being carried out with a gradient of 100% dichloromethane to 95/5 dichloromethane/methanol. 370 mg of 1,1-dimethylethyl (6-{[6-(morpholin-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate are thus obtained in the form of a white solid, the characteristics of which are as follows:

Fuente