Reacción #60453

Ecuación de reacción

sodium carbonate

4-[4-bromo-2-(4,4-dimethylcyclohexyl)phenyl]piperazine-1-carboxylic acid t-butyl ester

trifluoroacetic acid

dichloromethane

→

crude product

Rendimiento 103.7%

1-[4-Bromo-2-(4,4-dimethylcyclohexyl)phenyl]piperazine

Rendimiento 103.7%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe separated organic layer was washed with water and brine in that order
2. 2
   Secadodried over anhydrous sodium sulfate
3. 3
   FiltraciónThe desiccant was filtered off
4. 4
   Concentraciónthe filtrate was concentrated under reduced pressure
5. 5
   OtroThe residue was dried under reduced pressure

Procedimiento

A mixture of 4-[4-bromo-2-(4,4-dimethylcyclohexyl)phenyl]piperazine-1-carboxylic acid t-butyl ester (1.5 g, 3.32 mmol) produced in Example (3e), trifluoroacetic acid (3 mL, 38.7 mmol) and dichloromethane (6 mL) was stirred for 2 hours and 30 minutes at room temperature. Saturated aqueous solution of sodium carbonate was added to the reaction mixture and extraction was performed with ethyl acetate. The separated organic layer was washed with water and brine in that order and then dried over anhydrous sodium sulfate. The desiccant was filtered off and the filtrate was concentrated under reduced pressure. The residue was dried under reduced pressure to give 1.21 g of a crude product of the title compound as a brown oil.

Fuente