Reacción #60444

Ecuación de reacción

1-(2-methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine

hydrogen chloride

ethyl acetate

→

title compound

1-(2-Methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine hydrochloride

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe solution was concentrated
2. 2
   workup.ADDITIONdiethyl ether was added to the obtained residue
3. 3
   Otroto produce a solid
4. 4
   Otrothe supernatant diethyl ether solution was removed
5. 5
   OtroThe resultant solid was dried under reduced pressure

Procedimiento

After dissolving 1-(2-methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine (22 mg, 0.0588 mmol) in dichloromethane (1.5 mL), a 4N solution of hydrogen chloride in ethyl acetate (0.0294 mL, 0.1175 mmol) was added. The solution was concentrated, diethyl ether was added to the obtained residue to produce a solid, and the supernatant diethyl ether solution was removed. The resultant solid was dried under reduced pressure to give 14 mg of the title compound as a colorless solid.

Fuente