Reacción #60258

Ecuación de reacción

6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester

NaOH

→

pure desired product

Rendimiento 39.2%

6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid

Rendimiento 39.2%

Disolventes

ethyl acetate

water

HCl

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe layers are separated
2. 2
   Lavadothe organic layer is washed with brine
3. 3
   SecadoThe organic layer is dried (MgSO4)
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester 8b (58 mg, 0.146 mmol) is suspended in EtOH (2 mL) and 1 mL 2 N NaOH is added. After 16 hours, the reaction mixture is diluted with ethyl acetate, water, and 10% HCl solution. The layers are separated and the organic layer is washed with brine. The organic layer is dried (MgSO4) and concentrated under reduced pressure. Trituration with MeOH provides 22 mg (39%) pure desired product.

Fuente