Reacción #60032

Ecuación de reacción

tert-butyl 6-chloropyridine-3-carboxylate

ethylenediamine

→

tert-butyl 6-[(2-aminoethyl)amino]pyridine-3-carboxylate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed in vacuo
2. 2
   OtroThe residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide solution
3. 3
   ExtracciónThe aqueous layer was extracted a further three times with dichloromethane
4. 4
   LavadoThe combined organic layers were washed with water
5. 5
   Otrodried
6. 6
   Concentraciónconcentrated in vacuo

Procedimiento

The tert-butyl 6-chloropyridine-3-carboxylate was heated with ethylenediamine (20 ml) at 80° C. overnight. The solvent was removed in vacuo. The residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide solution. The aqueous layer was extracted a further three times with dichloromethane. The combined organic layers were washed with water, dried and concentrated in vacuo to give tert-butyl 6-[(2-aminoethyl)amino]pyridine-3-carboxylate.

Fuente