Reacción #60024

Ecuación de reacción

Ethyl 6-chloronicotinate

morpholine

Acetonitrile

→

ethyl 6-morpholin-4-ylpyridine-3-carboxylate

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITIn less than 5 minutes at this temperature
2. 2
   Otroa thick paste formed
3. 3
   Temperaturaheating
4. 4
   TemperaturaThe mixture was cooled
5. 5
   Extracciónextracted with ethyl acetate
6. 6
   OtroThe organic layer was dried
7. 7
   Concentraciónconcentrated in vacuo

Procedimiento

Ethyl 6-chloronicotinate (5.0 g) and morpholine (10 ml) were mixed and then heated to 100° C. In less than 5 minutes at this temperature, a thick paste formed. Acetonitrile (15 ml) was added and heating was continued overnight at 90° C. The mixture was cooled, diluted with water and extracted with ethyl acetate. The organic layer was dried and concentrated in vacuo to give ethyl 6-morpholin-4-ylpyridine-3-carboxylate as a white solid.

Fuente