Reacción #600064

Ecuación de reacción

acetic acid

4-(tert-butyldimethylsilanyloxy)-1-phenylbutan-1-one

2,5-difluorobenzoic acid hydrazide

acetic acid

→

2,5-difluorobenzoic acid [4-(tert-butyldimethylsilanyloxy)-1-phenylbutylidene]-hydrazide

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe mixture was stirred at 90° C. for 40 hours
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   workup.ADDITIONThe mixture of starting material and product
4. 4
   Otrowas carried forward without further purification

Procedimiento

To a solution of 4-(tert-butyldimethylsilanyloxy)-1-phenylbutan-1-one (420 mg, 1.5 mmol) in EtOH (4 mL) was added 2,5-difluorobenzoic acid hydrazide (260 mg, 1.5 mmol) and acetic acid (0.07 mL, 1.2 mmol). After stirring the reaction mixture at 90° C. for 5 hours, more acetic acid (0.1 mL) was added. The mixture was stirred at 90° C. for 40 hours and then concentrated under reduced pressure. The mixture of starting material and product was carried forward without further purification.

Fuente