Reacción #599729

Ecuación de reacción

4-isothiocyanatoquinoline

2-amino-cyanoacetamide

→

titled compound

5-amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

Disolventes

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 90 min
2. 2
   ConcentraciónThe reaction mixture was concentrated in vacuo
3. 3
   Otrothe resulting solids were collected
4. 4
   Lavadowashed with EtOAc

Procedimiento

A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.

Fuente