Reacción #599721

Ecuación de reacción

6-isothiocyanatoquinoline

2-amino-cyanoacetamide

→

titled compound

Rendimiento 65.4%

5-amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide

Rendimiento 65.4%

Disolventes

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 90 min
2. 2
   ConcentraciónThe reaction mixture was concentrated in vacuo
3. 3
   Otrothe residue was purified by silica gel column chromatography
4. 4
   Lavadoeluted with 2% MeOH in DCM

Procedimiento

A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.

Fuente