Reacción #59933

Ecuación de reacción

Magnesium sulfate

sodium hydroxide

lithium aluminum hydride

ethyl(2-ethyl-1,3-dioxolan-2-yl)acetate

→

title compound

Rendimiento 92.1%

2-(2-ethyl-1,3-dioxolan-2-yl)ethanol

Rendimiento 92.1%

Disolventes

water

water

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added under ice-
2. 2
   Temperaturacool
3. 3
   Temperaturacooled on ice
4. 4
   Temperaturacool
5. 5
   Filtraciónfiltrated through silica gel
6. 6
   ConcentraciónThe filtrate was concentrated under reduced pressure

Procedimiento

To a tetrahydrofuran (50 ml) suspension of lithium aluminum hydride (800 mg, 21.1 mmol), ethyl(2-ethyl-1,3-dioxolan-2-yl)acetate (3.85 g, 20.5 mmol) was added under ice-cool. The mixture was stirred at room temperature for one hour and 30 minutes and cooled on ice. Thereafter, water (0.8 ml), a 15% aqueous sodium hydroxide solution (0.8 ml), and water (2.4 ml) were sequentially added to the mixture under ice cool. Magnesium sulfate was added to the mixture and filtrated through silica gel. The filtrate was concentrated under reduced pressure to obtain the title compound (2.76 g, 92.1%) as an oil.

Fuente