Reacción #597021

ord-df53ab38a8a54446a39755d20d2a4fa3

Ecuación de reacción

CN1CCc2[nH]c3ccc(Cl)cc3c2C1
8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole
C=Cc1ccc(=O)n(C)c1
1-methyl-5-vinylpyridin-2(1H)-one
[K+].[OH-]
KOH
→
CN1CCc2c(c3cc(Cl)ccc3n2CCc2ccc(=O)n(C)c2)C1
title compound
CN1CCc2c(c3cc(Cl)ccc3n2CCc2ccc(=O)n(C)c2)C1
5-(2-(8-chloro-1,2,3,4-tetrahydro-2-methylpyrido[4,3-b]indol-5-yl)ethyl)-1-methylpyridin-2(1H)-one

Reactantes

CN1CCc2[nH]c3ccc(Cl)cc3c2C1
8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole
C=Cc1ccc(=O)n(C)c1
1-methyl-5-vinylpyridin-2(1H)-one
[K+].[OH-]
KOH

Reactivos

Ninguno

Disolventes

CN1CCCC1=O
NMP

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroranging between 25 deg C
  2. 2
    Otroto 100 deg C
  3. 3
    OtroThe product obtained
  4. 4
    Otrois isolated by preparative HPLC

Procedimiento

The title compound is prepared from a mixture of 8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, 1-methyl-5-vinylpyridin-2(1H)-one and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09096591B2uspto-grants-2015_08