Reacción #59619

Ecuación de reacción

5-amino-2-(2-phenylchroman-6-yloxy)pyridine

2-(3-methoxyphenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol

2-(3-Methoxyphenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol

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6-(5-Aminopyridin-2-yloxy)2-(3-methoxyphenyl)chroman-4-ol

Condiciones de reacción

Procedimiento

6-(5-Aminopyridin-2-yloxy)2-(3-methoxyphenyl)chroman-4-ol was prepared as described for 5-amino-2-(2-phenylchroman-6-yloxy)pyridine in Example 26 using 138 mg 2-(3-methoxyphenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol (Example 102) and 457 mg of Zn. 1H NMR (400 MHz, d6-DMSO) δ: 7.52 (d, 1H, J 3.0 Hz), 7.32 (t, 1H, J 15.7, 7.8 Hz), 7.06 (dd, 1H, 8.7, 3.0 Hz), 7.01-7.04 (m, 3H), 6.91 (dd, 1H, J 8.6, 2.4 Hz), 6.78-6.80 (m, 1H), 6.76 (d, 1H, J 8.7 Hz), 6.71 (d, 1H, J 8.6 Hz), 5.54 (d, 1H, J 6.5 Hz), 5.19 (d, 1H, J 10.6 Hz), 5.01 (s, 2H), 4.88-4.94 (m, 1H), 3.78 (s, 3H), 2.27-2.32 (m, 1H), 1.87-1.96 (m, 1H).

Fuente