Reacción #59618

Ecuación de reacción

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

2-(3-methoxyphenyl)chroman-4,6-diol

→

2-(3-Methoxyphenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol

Condiciones de reacción

Procedimiento

2-(3-Methoxyphenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 2-(3-methoxyphenyl)chroman-4,6-diol (Example 99(b)). 1H NMR (400 MHz, d6-DMSO) δ: 9.04 (d, 1H, J 2.9 Hz), 8.61 (dd, 1H, 9.1, 2.9 Hz), 7.34 (t, 1H, J 15.7, 7.8 Hz), 7.25 (d, 1H, J 2.4 Hz), 7.22 (d, 1H, 9.1 Hz), 7.00-7.06 (m, 3H), 6.92 (dd, 1H, J 8.8, 2.4 Hz), 6.88 (d, 1H, J 8.8 Hz), 5.64 (d, 1H, J 6.4 Hz), 5.27 (d, 1H, J 10.7 Hz), 4.95-5.00 (m, 1H), 3.79 (s, 3H), 2.30-2.35 (m, 1H), 1.92-2.01 (m, 1H).

Fuente