Reacción #59613
ord-7f4f9ecd055145d6b87c29cc2c6b31d4
Ecuación de reacción
Reactantes
Reactivos
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
6-(5-Aminopyridin-2-yloxy)-2-(2-methoxyphenyl)chroman-4-ol was prepared as described for 5-amino-2-(2-phenylchroman-6-yloxy)pyridine in Example 26 using 79 mg 2-(2-methoxyphenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol (Example 97(c)) and 262 mg of Zn. 1H NMR (400 MHz, d6-DMSO) δ: 7.52 (d, 1H, J 2.9 Hz), 7.47 (dd, 1H, J 7.5, 1.6 Hz), 7.33 (dt, 1H, J 8.5, 7.4, 1.6 Hz), 7.06 (d, 1H, J 2.8 Hz), 7.03-7.05 (m, 2H), 7.01 (d, 1H, J 7.4 Hz), 6.79 (dd, 1H, J 8.6, 2.8 Hz), 6.75 (d, 1H, J 8.7 Hz), 6.71 (d, 1H, J 8.6 Hz), 5.52 (d, 1H, J 6.5 Hz), 5.44 (d, 1H, J 10.5 Hz), 5.01 (s, 2H), 4.86-4.92 (m, 1H), 3.83 (s, 3H), 2.27-2.32 (m, 1H), 1.80-1.88 (m, 1H).