Reacción #596007

Ecuación de reacción

4-chloro-2-fluoro-1-iodobenzene

ethynyl(trimethyl)silane

→

desired product

Rendimiento 56.5%

((4-chloro-2-fluorophenyl)ethynyl)trimethylsilane

Rendimiento 56.5%

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mass quenched in water
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   Concentraciónconcentrated

Procedimiento

To a solution of 4-chloro-2-fluoro-1-iodobenzene (2.0 g, 7.8 mmol) in DMSO (10 mL) was added ethynyl(trimethyl)silane (1.14 g, 11.0 mmol), copper iodide (0.029 g, 0.15 mmol), bis(triphenylphosphine) palladium(II) chloride (0.218 g, 0.3 mmol) and TEA (1 mL). The reaction mass was stirred at RT for 4-5 h. The reaction mass quenched in water, passed through celite bed and extracted with ethyl acetate and concentrated to afford 1.0 g of desired product.

Fuente