Reacción #59580
ord-461ff9d0f402493b99eb79737cdb4dd3
Ecuación de reacción
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
2-(2,6-Difluorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 1.9 g of 2-(2,6-difluorophenyl)chroman-4,6-diol. 1H NMR (300 MHz, d6-DMSO) δ: 9.03 (d, 1H, J 2.9 Hz), 8.61 (dd, 1H, J 9.1, 2.9 Hz), 7.52 (m, 1H), 7.26-7.16 (m, 4H), 7.01 (dd, 1H, J 8.8, 2.9 Hz), 6.83 (d, 1H, 8.8 Hz), 5.69-5.64 (m, 2H), 4.98 (m, 1H), 2.37 (m, 1H), 2.29 (m, 1H).