Reacción #595417

Ecuación de reacción

3,6-dibromocarbazole

KOH

Ethyl bromoacetate

→

white solid

Rendimiento 96.4%

ethyl 2-(3,6-dibromo-9H-carbazol-9-yl)acetate

Rendimiento 96.4%

Disolventes

N,N-dimethylformamide

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGwas stirred at room temperature overnight
2. 2
   OtroThe reaction crude
3. 3
   Lavadowashed with 1M HCl and water
4. 4
   SecadoThe organic layer was dried with MgSO4
5. 5
   Concentraciónthe concentrated

Procedimiento

To a solution of 3,6-dibromocarbazole (325.0 mg, 1.0 mmol, 1 equiv) in anhydrous N,N-dimethylformamide (5 mL) was added crushed KOH (67.3 mg, 1.2 mmol, 1.2 equiv). The mixture was stirred for 30 minutes. Ethyl bromoacetate (277.2 μL, 2.5 mmol, 2.5 equiv) was added into the mixture and it was stirred at room temperature overnight. The reaction crude was diluted with ethyl acetate (30 mL) and washed with 1M HCl and water. The organic layer was dried with MgSO4 and the concentrated to afford 396.3 mg white solid as product (96.4%).

Fuente