Reacción #595414

Ecuación de reacción

product

1-chloro-3-(phenylamino)propan-2-ol

KOH

→

colorless oil

Rendimiento 95.0%

N-(oxiran-2-ylmethyl)aniline

Rendimiento 95.0%

Disolventes

EtOAc

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with 1M HCl and brine
2. 2
   SecadoThe organic layer was dried with MgSO4
3. 3
   Concentraciónconcentrated
4. 4
   Otroto give crude product
5. 5
   OtroIt was further purified by silica gel chromatography

Procedimiento

To a solution of the product of Step 3 (185.7 mg, 1.0 mmol, 1 equiv) in 1,4-dioxane (3.3 mL) was added KOH powder (67.3 mg, 1.2 mmol, 1.2 equiv). The mixture was stirred at room temperature for 24 hours. The mixture was diluted with EtOAc and washed with 1M HCl and brine. The organic layer was dried with MgSO4 and concentrated to give crude product. It was further purified by silica gel chromatography using 20% EtOAc/Hex to afford 141.8 mg colorless oil as product, yield 95.0%.

Fuente