Reacción #595385

Ecuación de reacción

compound 26A

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-hydroxybenzoic acid

NaOH

→

title compound

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-hydroxybenzoate

Disolventes

H2O

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe mixture was sonicated for ˜10 mins
2. 2
   OtroThe mixture was then dried under lyophilizaiton

Procedimiento

To a suspension of compound 26A (48 mg, 0.1 mmol) in H2O (20 mL) was added 0.1 M NaOH (1 mL), and the mixture was sonicated for ˜10 mins. The mixture was then dried under lyophilizaiton to give the title compound. LCMS (ESI) calc'd for C22H11ClF4N2NaO4 [M+H]+: 501. found: 501; 1H NMR (400 MHz, MeOD) δ 8.45 (1H, d, J=8.0), 7.91-7.76 (5H, m), 7.31 (1H, q, J=8.0 Hz), 7.20-7.17 (2H, m).

Fuente