Reacción #595347

Ecuación de reacción

compound

[5-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol

thionyl chloride

→

4-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazole

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroexcess thionyl chloride is then removed under reduced pressure
2. 2
   Lavadowashed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   SecadoThe organic phase is dried over magnesium sulfate
4. 4
   Otrothe solvent is removed on a rotary evaporator
5. 5
   OtroThe product obtained
6. 6
   Otrois used without further purification in the subsequent reactions

Procedimiento

269 mg (0.77 mmol) of the compound from Example 38A are initially charged in 0.43 ml (5.85 mmol) of thionyl chloride. The reaction mixture is stirred at RT for 12 h, and excess thionyl chloride is then removed under reduced pressure. The residue is taken up in 5 ml of ethyl acetate and washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reactions.

Fuente