Reacción #595335

Ecuación de reacción

4-fluoro-3-methylbenzamide

1,3-dichloro-acetone

sulfuric acid

→

4-(Chloromethyl)-2-(4-fluoro-3-methylphenyl)-1,3-oxazole

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA melt is formed
2. 2
   workup.STIRRINGstirred at RT overnight
3. 3
   OtroThe precipitate formed
4. 4
   Filtraciónis filtered off
5. 5
   Otrodried at 40° C. in a vacuum
6. 6
   Otrodrying cabinet overnight

Procedimiento

2.00 g (12.80 mmol) of 4-fluoro-3-methylbenzamide and 1.79 g (14.08 mmol) of 1,3-dichloro-acetone are stirred at 130° C. for 2 days. A melt is formed. The mixture is then cooled to RT, 3.0 ml of conc. sulfuric acid are added carefully at this temperature and the mixture is stirred for 15 min. The resulting suspension is poured into 20 ml of ice-water and stirred at RT overnight. The precipitate formed is filtered off and dried at 40° C. in a vacuum drying cabinet overnight.

Fuente