Reacción #595321

Ecuación de reacción

Cyclopropanesulfonyl chloride

BuOH

pyridine

→

oil

Rendimiento 71.0%

Butyl cyclopropanesulfonate

Rendimiento 71.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was slowly warmed at room temperature
2. 2
   OtroThe solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe resulting white solid was dissolved in CHCl3
4. 4
   LavadoThe organic phase was washed with water, brine
5. 5
   Secadodried (MgSO4)
6. 6
   Concentraciónconcentrated

Procedimiento

Cyclopropanesulfonyl chloride (5 g, 35 mmol, 1 eq) was dissolved in an excess BuOH (20 ml), the reaction mixture was cooled at −10° C. and pyridine (5.8 mL, 70 mmol, 2 eq) was slowly added dropwise. The mixture was slowly warmed at room temperature and stirred overnight. The solvent was removed under reduced pressure and the resulting white solid was dissolved in CHCl3. The organic phase was washed with water, brine and dried (MgSO4) and concentrated to give an oil (4.8 g, 24.9 mmol, 71%). 1H NMR (300 MHz, CDCl3): δ 4.25 (t, 2H), 2.46 (m, 1H), 1.74 (m, 2H), 1.45 (m, 2H), 1.25 (dd, 2H), 1.09 (dd, 2H), 0.93 (t, 3H).

Fuente