Reacción #595103

Ecuación de reacción

5-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde

lithium aluminum hydride

methyl 4-hydroxybenzoate

tributylphosphine

1,1′-(azodicarbonyl)dipiperidine

Sodium sulfate decahydrate

→

title compound

Rendimiento 54.4%

methyl 4-{[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]methoxy}benzoate

Rendimiento 54.4%

Disolventes

tetrahydrofuran

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato warm to room temperature
2. 2
   workup.STIRRINGstirred for 30 min
3. 3
   FiltraciónThe insoluble material was filtered off
4. 4
   Concentraciónthe filtrate was concentrated
5. 5
   Otroto give a colorless oil
6. 6
   workup.ADDITIONwas added at room temperature
7. 7
   workup.STIRRINGThe mixture was stirred at room temperature for 1 hr
8. 8
   ConcentraciónThe reaction mixture was concentrated under reduced pressure
9. 9
   Otrothe residue was purified by silica gel column chromatography (10%-65% ethyl acetate/hexane)

Procedimiento

To a solution of 5-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde (1.02 g, 5.0 mmol) in tetrahydrofuran (10 mL) was added lithium aluminum hydride (200 mg, 5.27 mmol) at 0° C., and the mixture was stirred at 0° C. for 1 hr. Sodium sulfate decahydrate (1.0 g) was added to the reaction mixture, and the mixture was allowed to warm to room temperature and stirred for 30 min. The insoluble material was filtered off, and the filtrate was concentrated to give a colorless oil. To this oil were added methyl 4-hydroxybenzoate (910 mg, 6.0 mmol), tributylphosphine (1.61 g, 8.0 mmol) and tetrahydrofuran (10 mL), and 1,1′-(azodicarbonyl)dipiperidine (1.50 g, 5.94 mmol) was added at room temperature. The mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (10%-65% ethyl acetate/hexane) to give the title compound (925 mg, yield 54%, 2 steps) as a yellow oil.

Fuente