Reacción #5949

Ecuación de reacción

6-aminobenzothiazole

phosgene

→

6-benzothiazolylisocyanate

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 6 h
2. 2
   OtroThe solvent was removed under reduced pressure

Procedimiento

A mixture of 6-aminobenzothiazole (600 mg; 4 mmol) in toluene (40 ml) and phosgene (20 ml 20% in toluene; 40 mmol) was refluxed for 6 h. The solvent was removed under reduced pressure to give crude 6-benzothiazolylisocyanate. To the crude product was added 3-[4-(4-chlorophenyl)-1-piperazinyl]propanol (500 mg; 2.0 mmol) in toluene (20 ml) and refluxed for 16 h. The precipitate was isolated and recrystallized from methanol/ether to give 440 mg of the title compound. M.p. 210°-213° C. MS (70 eV): m/z 430 (13%, M+), 254 (32), 209 (77), 176 (100), 121 (38), 70 (83).

Fuente