Reacción #59443

Ecuación de reacción

piperidine

Malononitrile

2-fluorobenzaldehyde

→

title material

Rendimiento 28.3%

2-(2-Fluoro-benzylidene)-malononitrile

Rendimiento 28.3%

Disolventes

iso-propyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowere placed in a vessel
2. 2
   Otrowhich was irradiated in a 300 W single mode microwave for 15 seconds
3. 3
   Filtraciónfiltered
4. 4
   Otroevaporated
5. 5
   Filtraciónfiltered through a pad of Magnasol
6. 6
   Otroevaporated
7. 7
   Otrorecrystallized from ethanol

Procedimiento

Malononitrile (3.303 g, 50 mmol), 2-fluorobenzaldehyde (6.205 g, 50 mmol), 1 g of molecular sieves, and 500 mg of a resin bound piperidine (described in Tetrahedron Lett., 1999, 40, 7031-33) were placed in a vessel which was irradiated in a 300 W single mode microwave for 15 seconds. The reaction mixture was taken up in iso-propyl acetate, filtered, evaporated, taken up in dichloromethane, filtered through a pad of Magnasol, evaporated, and recrystallized from ethanol to yield 2.435 g of the title material as a crystalline solid,

Fuente