Reacción #5914

Ecuación de reacción

4-Fluoroaniline

potassium carbonate

18-Crown-6

ethylbromoacetate

→

Ethyl N-(4-fluorophenyl)glycine

Disolventes

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction was heated to reflux

Procedimiento

4-Fluoroaniline (5 g), potassium carbonate (3.11 g) and a catalytic amount of 18-Crown-6 were stirred together in 50 ml of ethanol. A solution of ethylbromoacetate (7.52 g) in 25 ml of ethanol was added dropwise and the reaction was heated to reflux.

Fuente