Reacción #591135

ord-d3d56c65686f44b1b11af357bc595726

Ecuación de reacción

CNC(=O)COc1cc(S(=O)(=O)c2cccc(F)c2)ccc1C1CCN(C(=O)OC(C)(C)C)C1
3-[4-(3-Fluoro-benzenesulfonyl)-2-methylcarbamoylmethoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
Cl
HCl
→
CNC(=O)COc1cc(S(=O)(=O)c2cccc(F)c2)ccc1C1CCNC1
2-[5-(3-Fluoro-benzenesulfonyl)-2-pyrrolidin-3-yl-phenoxy]-N-methyl-acetamide

Reactantes

CNC(=O)COc1cc(S(=O)(=O)c2cccc(F)c2)ccc1C1CCN(C(=O)OC(C)(C)C)C1
3-[4-(3-Fluoro-benzenesulfonyl)-2-methylcarbamoylmethoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
Cl
HCl

Reactivos

Ninguno

Disolventes

C1COCCO1
1,4-dioxane

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

3-[4-(3-Fluoro-benzenesulfonyl)-2-methylcarbamoylmethoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester was deprotected using HCl in 1,4-dioxane following the procedure described in Example 13, to afford 2-[5-(3-Fluoro-benzenesulfonyl)-2-pyrrolidin-3-yl-phenoxy]-N-methyl-acetamide as a hydrochloride salt. MS (M+H)=393.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07776910B2uspto-grants-2010_08