Reacción #59045

Ecuación de reacción

Water

Methanesulfonyl chloride

ethyl [4′-(2-hydroxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate

triethylamine

→

ethyl [4′-(2-methanesulfonyloxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate

Disolventes

ethyl acetate

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hr
3. 3
   OtroThe organic layer was separated
4. 4
   Lavadowashed with water and brine
5. 5
   Secadodried over anhydrous magnesium sulfate
6. 6
   OtroThe solvent was evaporated under reduced pressure

Procedimiento

Methanesulfonyl chloride (0.17 mL) was added to an ice-cooled mixture of ethyl [4′-(2-hydroxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate (0.58 g) and triethylamine (0.36 mL) in methylene chloride (5 mL) with stirring, and the mixture was stirred at room temperature for 1 hr. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford ethyl [4′-(2-methanesulfonyloxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate.

Fuente