Reacción #590325

Ecuación de reacción

water

diethyl ether

5-nitroindazole

N-iodosuccinimide

→

title compound

Rendimiento 91.3%

3-Iodo-5-nitro-1H-indazole

Rendimiento 91.3%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool, to the reaction mixture
2. 2
   Filtraciónthe resulting crystals were collected by filtration
3. 3
   LavadoThe crystals were sequentially washed with water, isopropanol and diethyl ether

Procedimiento

To a solution of 17.0 g of 5-nitroindazole in 100 ml dimethylformamide was added 24.6 g of N-iodosuccinimide at room temperature, and the mixture was stirred at 80° C. for 7 hours. After standing to cool, to the reaction mixture were added 150 ml of water and 200 ml of diethyl ether, and the resulting crystals were collected by filtration. The crystals were sequentially washed with water, isopropanol and diethyl ether, to give 27.5 g of the title compound as colorless crystals.

Fuente