Reacción #59019

Ecuación de reacción

hydrochloric acid

Trifluoromethanesulfonic anhydride

methyl 4-hydroxy-2-methoxybenzoate

pyridine

→

methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate

Disolventes

ethyl acetate

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled
2. 2
   workup.STIRRINGThe mixture was stirred at room temperature for 30 min
3. 3
   ExtracciónThe resulting mixture was extracted with ethyl acetate
4. 4
   LavadoThe organic layer was washed with water and brine
5. 5
   Secadodried over anhydrous magnesium sulfate
6. 6
   OtroThe solvent was evaporated under reduced pressure

Procedimiento

Trifluoromethanesulfonic anhydride (2.24 mL) was added to an ice-cooled mixture of methyl 4-hydroxy-2-methoxybenzoate (2.02 g) and pyridine (0.14 mL) in methylene chloride (15 mL) with stirring. The mixture was stirred at room temperature for 30 min, and poured into a mixture of hydrochloric acid and ethyl acetate. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate (3.49 g).

Fuente