Reacción #589101

Ecuación de reacción

diethyl oxide water

Sodium borohydride

tricyclohexyltin hydroxide

→

Tricyclohexyltin Hydride

Disolventes

diethyl oxide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONcarefully added
2. 2
   OtroAfter separation
3. 3
   Secadothe organic layer was dried over magnesium sulphate
4. 4
   Otroevaporated under reduced pressure
5. 5
   workup.DISTILLATIONThe crude product was distilled under high vacuum
6. 6
   Otroto afford

Procedimiento

A mixture (400 mL) of diethyl oxide:water 1:1 was cooled at 0° C. under nitrogen in a three-necked flask of 1 L. Sodium borohydride (3 g, 79.4 mmol) and then tricyclohexyltin hydroxide (30 g, 62.2 mmol) were successively and carefully added. After addition of 100 mL of diethyl oxide, the mixture was stirred 2 days at room temperature. After separation, the organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The crude product was distilled under high vacuum to afford, a colourless oil (23.23 g; 63 mmol).

Fuente