Reacción #58871

Ecuación de reacción

2-fluoro-5-bromophenol

potassium carbonate

sodium iodide

4-bromo-1,1-difluoro-1-butene

→

4-bromo-2-(4,4-difluorobut-3-enyloxy)-1-fluorobenzene

Rendimiento 63.0%

Disolventes

dichloromethane

methyl ethyl ketone

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas placed in a pressure vessel
2. 2
   Temperaturaheated in a 82° oil bath for 15 hours
3. 3
   TemperaturaThe reaction mixture was cooled
4. 4
   Filtraciónfiltered
5. 5
   Otroevaporated in vacuo
6. 6
   OtroThe resultant residue was purified by flash chromatography (silica gel, eluant

Procedimiento

A mixture of 2-fluoro-5-bromophenol (2.40 g), potassium carbonate (2.31 m), Aliquat 336 (5 drops), sodium iodide (catalytic) and 4-bromo-1,1-difluoro-1-butene (1.79 mL) in methyl ethyl ketone was placed in a pressure vessel and heated in a 82° oil bath for 15 hours. The reaction mixture was cooled, diluted with dichloromethane, filtered and evaporated in vacuo. The resultant residue was purified by flash chromatography (silica gel, eluant: 2.5% ethyl acetate/hexane to afford 4-bromo-2-(4,4-difluorobut-3-enyloxy)-1-fluorobenzene, 2.23 g (63% yield), identified by NMR analysis.

Fuente