Reacción #587086

Ecuación de reacción

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst is filtered off
2. 2
   Otrothe filtrate is evaporated in vacuo
3. 3
   OtroThe residue from evaporation
4. 4
   Otrois further used directly for the next reaction

Procedimiento

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. The reaction mixture is hydrogenated with hydrogen in the hydrogenation apparatus at room temperature. The catalyst is filtered off and the filtrate is evaporated in vacuo. The residue from evaporation is further used directly for the next reaction.

Fuente