Reacción #587085

Ecuación de reacción

ethyl 4-nitro-1H-imidazole-2-carboxylate

cyclopropylmethyl bromide

potassium carbonate

→

Ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

Disolventes

DMF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Extracciónextracted four times with ethyl acetate
3. 3
   LavadoThe combined organic phases are washed once with water and three times with saturated sodium chloride solution
4. 4
   Secadodried with magnesium sulphate
5. 5
   Otroevaporated in vacuo
6. 6
   OtroThe crystalline residue is further used directly for the next reaction

Procedimiento

15 g (81 mmol) of ethyl 4-nitro-1H-imidazole-2-carboxylate are stirred together with 13.13 g (97.2 mmol) of cyclopropylmethyl bromide and 22.4 g (162 mmol) of potassium carbonate in 165 ml of DMF at 80° C. under argon for 1 h. After cooling, the reaction mixture is diluted with water and extracted four times with ethyl acetate. The combined organic phases are washed once with water and three times with saturated sodium chloride solution, dried with magnesium sulphate and evaporated in vacuo. The crystalline residue is further used directly for the next reaction.

Fuente