Reacción #586102

Ecuación de reacción

N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide

potassium hydroxide

methanol

→

3-(1,1-dimethypropyl)-2-methyl-phenylamine

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux temperature for 15 hours
2. 2
   workup.ADDITIONis added
3. 3
   Extracciónthe reaction mixture is extracted with ethylacetate
4. 4
   SecadoAfter drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum
5. 5
   Otrothe product is purified by destillation (bp. ca. 70° C., 13,33 Pa)

Procedimiento

2,21 g (10.77 mmol) N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide, 1,42 g (21.54 mmol) 85% potassium hydroxide and 9 ml methanol are heated under stirring at reflux temperature for 15 hours. After cooling 100 ml of water is added and the reaction mixture is extracted with ethylacetate. After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum, the product is purified by destillation (bp. ca. 70° C., 13,33 Pa). This gives 1.7 g of 2-Methyl-3-(1,1-dimethylpropyl)phenylamine in the form of a colourless oil (89% of theory).

Fuente