Reacción #58524

Ecuación de reacción

product

1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid tert-butyl ester

trifluoroacetic acid

→

1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroNext, the solvent was evaporated
2. 2
   workup.ADDITIONtoluene (50 ml) was added
3. 3
   Otrosubsequently evaporated in vacuo at 40° C.
4. 4
   Otroto remove residual TFA
5. 5
   OtroThe crude subtitle product was used without further purification

Procedimiento

The product of step b) (2.6 g, 5.2 mmol) in CH2Cl2 (25 ml) and trifluoroacetic acid (TFA) (75 ml) was stirred at 220C for 16 hours. Next, the solvent was evaporated and toluene (50 ml) was added and subsequently evaporated in vacuo at 40° C. to remove residual TFA. The crude subtitle product was used without further purification.

Fuente