Reacción #58478

Ecuación de reacción

KCN

4-oxo-tetrahydro furane 3-carboxylic acid methyl ester

H2SO4

→

4-cyano-tetrahydro furane 3-carboxylic acid methyl ester

Disolventes

water

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThen the organic solution was separated
2. 2
   Lavadothe salts were washed twice with benzene
3. 3
   Secadodried over sodium sulfate
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

To a stirred solution of 3.9 g (60 mmol) KCN in 5.5 ml of water at 4° C., a solution of 2.9 g (20 mmol) of 4-oxo-tetrahydro furane 3-carboxylic acid methyl ester in ether (26 ml) was added. To the precipitate of salts, 3.5 ml H2SO4 (18 N) was added and stirred for 16 hours. Then the organic solution was separated, the salts were washed twice with benzene, dried over sodium sulfate and concentrated in vacuo to give 4-cyano-tetrahydro furane 3-carboxylic acid methyl ester.

Fuente