Reacción #5837

Ecuación de reacción

product

N-[2-(4-Chlorocinnamylamino)ethyl]-5-Isoquinolinesulfonamide

methyl iodide

→

title compound

N-[2-(4-Chloro-N-Methylcinnamylamino)ethyl]-5-Isoquinolinesulfonamide

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroExcess methyl iodide was immediately evaporated off under a reduced pressure
2. 2
   Otroresulting residue
3. 3
   Otrowas purified on a silica gel column (silica gel 50 g, eluant: 5% methanol in chloroform)

Procedimiento

1.50 g of the product of Example 172 was dissolved in 10 ml of chloroform, to the solution was added 3 ml of methyl iodide at a room temperature, and the mixture was stirred for 40 minutes. Excess methyl iodide was immediately evaporated off under a reduced pressure, and resulting residue was purified on a silica gel column (silica gel 50 g, eluant: 5% methanol in chloroform), to obtain 720 mg of the title compound in a colorless amorphous form.

Fuente