Reacción #58206

Ecuación de reacción

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide

hydrochloric acid

sodium hydroxide

→

oily product

Rendimiento 94.0%

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]amine

Rendimiento 94.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture is refluxed for 4 hours
2. 2
   Temperaturacooled in an ice bath
3. 3
   Extracciónextracted three times with ethyl acetate
4. 4
   LavadoThe combined extracts are washed with water and with brine
5. 5
   Secadodried over anhydrous sodium sulfate
6. 6
   Otroevaporated under reduced pressure

Procedimiento

4 g (12.9 mmol) of N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide are poured into 13 mL of 5N hydrochloric acid. The mixture is refluxed for 4 hours and then cooled in an ice bath, basified with 35% sodium hydroxide and extracted three times with ethyl acetate. The combined extracts are washed with water and with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. 3.2 g of oily product are obtained (94% yield).

Fuente