Reacción #58131

Ecuación de reacción

8-benzyloxy-5-oxiranyl-1H-quinolin-2-one

1-(4-trifluoromethyl-benzyl)-cyclopropylamine

→

8-benzyloxy-5-{1-hydroxy-2-[1-(4-trifluoromethyl-benzyl)-cyclopropylamino]-ethyl}-1H-quinolin-2-one

Condiciones de reacción

Procedimiento

Reaction of 587 mg (2.0 mmol) 8-benzyloxy-5-oxiranyl-1H-quinolin-2-one and 710 mg (3.3 mmol) 1-(4-trifluoromethyl-benzyl)-cyclopropylamine is carried out analogously to Example 40a43a). Yield: 322 mg (32%); mass spectroscopy: [M+H]+=509.

Fuente