Reacción #58039

Ecuación de reacción

trans-[4-(benzylimino-methyl)-cyclohexyl]-carbamic acid tert-butyl ester

oxalic acid

→

trans-(4-Formyl-cyclohexyl)-carbamic acid tert-butyl ester

Rendimiento 80.0%

Disolventes

water THF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated under reduced pressure and methylene chloride (50 mL)
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   OtroThe organic phase was dried
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

A solution of trans-[4-(benzylimino-methyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.50 g, 8.00 mmol) and oxalic acid (0.80 g) in water/THF (50 mL, 1:1) was stirred for 10 h at room temperature. The reaction mixture was concentrated under reduced pressure and methylene chloride (50 mL) was added to the residue. The organic phase was dried and concentrated under reduced pressure to give trans-(4-Formyl-cyclohexyl)-carbamic acid tert-butyl ester (1.3 g, 80%).

Fuente