Reacción #57999

Ecuación de reacción

tert-butylamine

(chloromethyl)trimethylsilane

NaOH

→

title compound 77

N-tert-butyl-N-(trimethylsilylmethyl)amine

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to ambient temperature
2. 2
   Extracciónextracted three times with diethyl ether
3. 3
   LavadoThe combined organic extracts were washed with brine
4. 4
   Secadodried (MgSO4)
5. 5
   Otrothe volatiles evaporated in vacuo
6. 6
   workup.DISTILLATIONDistillation (atmospheric pressure; ˜135° C.) of the residual liquid

Procedimiento

A mixture of tert-butylamine (18.0 mL, 171 mmol) and (chloromethyl)trimethylsilane (7.00 g, 57.1 mmol) was heated in a thick-walled glass tube at 200° C. overnight. After cooling to ambient temperature, the reaction mixture was poured into 1 N NaOH and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4), and the volatiles evaporated in vacuo. Distillation (atmospheric pressure; ˜135° C.) of the residual liquid gave the title compound 77 as a colorless liquid.

Fuente