Reacción #57995

Ecuación de reacción

Ether

methyl 4-(2-tert-butoxycarbonylaminoethylsulfanyl)benzoate

HCl

dioxane

→

methyl 4-(2-aminoethylsulfanyl)benzoate hydrochloride

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe mixture was filtered
2. 2
   Lavadowashed with ether
3. 3
   Otropumped dry

Procedimiento

A solution of methyl 4-(2-tert-butoxycarbonylaminoethylsulfanyl)benzoate (1.00 g, 3.21 mmol) in dichloromethane (8 ml) was treated with a solution of HCl in dioxane (4M, 8 ml, 10 eq.) at room temperature for 3 h. Ether (100 ml) was added and the mixture was filtered, washed with ether and pumped dry to give methyl 4-(2-aminoethylsulfanyl)benzoate hydrochloride.

Fuente