Reacción #578431

Ecuación de reacción

triphenylsulfonium chloride

sodium 1,1-difluoro-2-tosyloxyethanesulfonate

→

triphenylsulfonium 1,1-difluoro-2-tosyloxyethanesulfonate

Rendimiento 74.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrosynthesized in Synthesis Example 9
2. 2
   OtroThe organic layer was separated
3. 3
   Lavadowashed with 20 g of water three times
4. 4
   ConcentraciónThe organic layer was concentrated
5. 5
   workup.ADDITION10 g of diisopropyl ether was added to the residue for crystallization
6. 6
   FiltraciónThe crystals were filtered
7. 7
   Otrodried
8. 8
   Otroobtaining the target compound

Procedimiento

To 62 g of dichloromethane were added an amount (corresponding to 0.031 mole) of the triphenylsulfonium chloride aqueous solution of Synthesis Example 1 and 1.1 g (0.033 mole) of sodium 1,1-difluoro-2-tosyloxyethanesulfonate synthesized in Synthesis Example 9, followed by stirring. The organic layer was separated and washed with 20 g of water three times. The organic layer was concentrated and 10 g of diisopropyl ether was added to the residue for crystallization. The crystals were filtered and dried, obtaining the target compound. White crystals, 1.3 g (yield 74%).

Fuente