Reacción #577255

Ecuación de reacción

19

4-acetamido-N-((4-acetylmorpholin-2-yl)methyl)-2-ethoxybenzamide

N-chlorosuccinimide

→

20

Rendimiento 67.4%

4-acetamido-N-((4-acetylmorpholin-2-yl)methyl)-5-chloro-2-ethoxybenzamide

Rendimiento 67.4%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was then concentrated under reduced pressure to dryness
2. 2
   OtroThe residue was triturated with H2O
3. 3
   Otrothe resulting solids were removed by filtration
4. 4
   Otrorecrystallized from CH3OH

Procedimiento

A solution of 19 (1.78 g, 4.9 mmol) and N-chlorosuccinimide (0.687 g, 5.1 mmol, 1.05 equiv) in DMF (30 mL) was stirred for 1 h at 70° C. The reaction mixture was then concentrated under reduced pressure to dryness. The residue was triturated with H2O and the resulting solids were removed by filtration and recrystallized from CH3OH to yield 20 (1.314 g).

Fuente