Reacción #577247

Ecuación de reacción

4-(2-hydroxy-ethyl)-phenol

potassium carbonate

benzyl bromide

→

2-(4-Benzyloxy-phenyl)-ethanol

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction mixture is then filtered off trough celite
2. 2
   Concentraciónconcentrated under vacuum

Procedimiento

To a solution of 4-(2-hydroxy-ethyl)-phenol (50 g, 0.36 mol) in ethanol (400 ml) is added potassium carbonate (75 g, 0.54 mol, 1.5 eq) and benzyl bromide (47.2 ml, 0.39 mol, 1.1 eq), the reaction mixture is stirred at room temperature overnight. The reaction mixture is then filtered off trough celite and concentrated under vacuum. 2-(4-Benzyloxy-phenyl)-ethanol is isolated after crystallization with diethyl ether (82.6 g, 95%).

Fuente