Reacción #577198

Ecuación de reacción

4-amino-4′-fluorobenzophenone

Acetylide

sodium acetylide

carbonyl

4-amino-4′-fluorobenzophenone

→

1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol

Disolventes

acetylene

Condiciones de reacción

Procedimiento

Referring now to FIG. 2, wherein one non-limiting approach to the 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol is presented, 4,4′-difluorobenzophenone (7) is reacted with a secondary amine HNR′″R″″ to give the 4-amino-4′-fluorobenzophenone 8, where R′″ and R″″ may be the same as R36 and R37, respectively, as set forth and claimed herein. Acetylide anion, for example, sodium acetylide in acetylene saturated dimethylformamide, is added to the carbonyl of 4-amino-4′-fluorobenzophenone 8 to give, upon aqueous workup, 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol 9.

Fuente