Reacción #577131

ord-115ebaf4e5d94608ab014f3be21bf72b

Ecuación de reacción

COC(=O)c1cccc(C)c1
methyl 3-methylbenzoate
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)C(C)C
A-208
O=C(Cc1ccncc1)c1ccc(F)cc1
4-fluorobenzoyl-4-pyridinyl methane
Cc1ccncn1
4-methyl-pyrimidine
→
Cc1cccc(-c2n[nH]cc2-c2ccncn2)c1
4-[3-(3-methylphenyl)-1H-pyrazol-4-yl]pyrimidine

Reactantes

COC(=O)c1cccc(C)c1
methyl 3-methylbenzoate
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)C(C)C
A-208
—
1-methyl-3-(4′-pyrimidinylacetyl)benzene
O=C(Cc1ccncc1)c1ccc(F)cc1
4-fluorobenzoyl-4-pyridinyl methane
Cc1ccncn1
4-methyl-pyrimidine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThis compound was prepared by the same procedure
  2. 2
    Otroprepared

Procedimiento

This compound was prepared by the same procedure as described for Example A-208 except that 1-methyl-3-(4′-pyrimidinylacetyl)benzene (prepared as set forth in Step 1 of Example A-19 from 4-methyl-pyrimidine and methyl 3-methylbenzoate) was used in place of 4-fluorobenzoyl-4-pyridinyl methane.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06979686B1uspto-grants-2005_12