Reacción #57696

Ecuación de reacción

5-iodo-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester

iodomethane

K2CO3

→

5-iodo-4-methoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester

Rendimiento 101.8%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe reaction mixture was washed with brine
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe combined ethyl acetate layers were washed with brine
4. 4
   OtroRemoval of the solvent

Procedimiento

To 748 mg (2 mmol) of 5-iodo-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester was added 1.42 g (10 mmol) of iodomethane, 553 mg (4 mmol) of K2CO3 and 10 mL of DMF. The mixture was stirred at room temperature overnight. The reaction mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine. Removal of the solvent gave 790 mg (100% yield) of 5-iodo-4-methoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester as a pale brown oil.

Fuente