Reacción #576683

Ecuación de reacción

1,8-dichloroanthraquinone

ammonia

→

1,8-dichloroanthracene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was refluxed for 3 hours
2. 2
   Otrothe solid was separated off via a Büchner funnel
3. 3
   ExtracciónThe aqueous phase was extracted three times with 150 ml each time of dichloromethane
4. 4
   Extracciónthe solid was extracted a number of times with dichloromethane
5. 5
   workup.ADDITIONwhile being treated with ultrasound
6. 6
   SecadoThe combined organic phases were dried over magnesium sulfate
7. 7
   Otrofreed of the solvent on a rotary evaporator
8. 8
   Temperatura65 ml of 12M hydrochloric acid and the mixture was refluxed for three hours
9. 9
   OtroThe solvent was subsequently removed under reduced pressure
10. 10
    Lavadothe solution was washed with saturated sodium hydrogen carbonate solution
11. 11
    Secadodried over magnesium sulfate
12. 12
    OtroRemoval of the solvent

Procedimiento

25 g (91 mmol) of 1,8-dichloroanthraquinone and 65 g (1 mol) of Zn dust were suspended in 1 l of a 20% strength by weight aqueous ammonia solution and the mixture was refluxed for 3 hours. After cooling to room temperature, the solid was separated off via a Büchner funnel. The aqueous phase was extracted three times with 150 ml each time of dichloromethane; the solid was extracted a number of times with dichloromethane while being treated with ultrasound. The combined organic phases were dried over magnesium sulfate and freed of the solvent on a rotary evaporator. The solid, whitish yellow residue was suspended in 600 ml of propanol and 65 ml of 12M hydrochloric acid and the mixture was refluxed for three hours. The solvent was subsequently removed under reduced pressure, the residue was taken up in dichloromethane, the solution was washed with saturated sodium hydrogen carbonate solution and dried over magnesium sulfate. Removal of the solvent gave 1,8-dichloroanthracene as a yellow solid which was recrystallized from propanol.

Fuente